Regis Philbin, Charles Grodin, Susan Lucci, Greg Giraldo, Kathleen Edwards

Whoopi Goldberg (a former talk-show host in her own right) is the latest to fill in for Dave during his extended bout with shingles. She starts the monologue by announcing that ""tonight's show is in color,"" and then points out that the CBS Orchestra was once again the house band of last weekend's Rock n' Roll Hall of Fame induction ceremony. Also, comedian Andy Vastola makes his network television debut.